Logo Microglia and serotonin axons

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Welcome to the Janusonis Laboratory at UC Santa Barbara!

Our laboratory studies the brain serotonin matrix and its interactions with other cellular elements. Serotonin molecules are ancient signal carriers that control the behavior of a shark, the cognition of a human, and many other vertebrate neuroprocesses. In particular, we are interested in the communication between serotonin-releasing axons and microglia and in functional relationships between serotonergic varicosities and blood platelets. Some of these problems have immediate clinical relevance: nearly all mental disorders have been associated with dysfunction in serotonin signaling, and the platelet hyperserotonemia of autism remains an enigma after half a century of research. We use a wide range of approaches that include molecular neurobiology, comparative neuroanatomy, and complex-systems methods.




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