Welcome to the Janusonis Laboratory at UC Santa Barbara!
Our laboratory studies the brain serotonin matrix and its interactions with other cellular elements. Serotonin molecules are ancient signal carriers that control the behavior of a shark, the cognition of a human, and many other vertebrate neuroprocesses. In particular, we are interested in the stochastic organization of serotonin-releasing axons and their functional relationships with microglia and blood platelets. Some of these problems have immediate clinical relevance: nearly all mental disorders have been associated with dysfunction in serotonin signaling, and the platelet hyperserotonemia of autism remains an enigma after half a century of research. We use a wide range of approaches that include molecular neurobiology, comparative neuroanatomy, and complex-systems methods.
- We anticipate a two-year postdoctoral researcher position starting in July 2018. The project investigates the stochastic process that drives serotonergic fibers in the brain. Candidates should be interested in interdisciplinary research and have a strong background in computational neuroscience and/or automated image analysis and/or stochastic processes. For more information, please contact Dr. Skirmantas Janusonis.
- The laboratory has been awarded a Challenge Grant by the California NanoSystems Institute (Brain Serotonergic Fibers: From a Single-cell Stochastic Process to Cognition in a Matrix). (December 2017)
- Riley Demos has been awarded an URCA grant. (December 2017)
- Norma Brown and Keon Youssefzadeh have been awarded an URCA grant. (December 2017)
- Some galeomorph sharks express a mammalian microglia-specific protein in radial ependymoglia of the telencephalon. Brain Behav. Evol. 91: 17-30.
- A receptor-based analysis of local ecosystems in the human brain. BMC Neurosci. 18: 33.
- Serotonin 5-HT4 receptors modulate the development of glutamatergic input to the dorsal raphe nucleus. Neurosci. Lett. 640: 111-116.
- Serotonin in space: Understanding single fibers. ACS Chem. Neurosci. 8: 893-896.