Welcome to the Janusonis Laboratory at UC Santa Barbara!
Our laboratory studies the brain serotonin matrix and its interactions with other cellular elements. Serotonin molecules are ancient signal carriers that control the behavior of a shark, the cognition of a human, and many other vertebrate neuroprocesses. In particular, we are interested in the stochastic organization of serotonin-releasing axons and their functional relationships with microglia and blood platelets. Some of these problems have immediate clinical relevance: nearly all mental disorders have been associated with dysfunction in serotonin signaling, and the platelet hyperserotonemia of autism remains an enigma after half a century of research. We use a wide range of approaches that include molecular neurobiology, comparative neuroanatomy, and complex-systems methods.
Souring Over UCSB
- A postdoctoral researcher position is available in a project that investigates the self-organization of brain serotonergic fibers. Candidates should have experience in one or more of the following areas: advanced microscopy, neuronal cell cultures, computer analysis of 3D-images (with programming experience), or modeling of stochastic processes.
- The laboratory is currently recruiting new Ph.D. students. All application materials must be submitted by December 1, 2019. For more information about the application process, please see here.
- Our model of serotonergic fibers makes the cover of a special anniversary issue of Biochimie. (April 2019)
- We are among the first national teams to be awarded access to Frontera, a next-generation NSF supercomputer. (March 2019)
- The laboratory has been awarded a Challenge - Program Development Grant by the California NanoSystems Institute (CNSI). (February 2019)
- The laboratory has been awarded a CRCNS grant by the National Science Foundation (NSF). (August 2018)
- Serotonergic axons as 3D-walks. ACS Chemical Neuroscience (in press).
- A stochastic approach to serotonergic fibers in mental disorders. Biochimie 161: 15-22.
- Some galeomorph sharks express a mammalian microglia-specific protein in radial ependymoglia of the telencephalon. Brain Behav. Evol. 91: 17-30.