Welcome to the Janusonis Laboratory at UC Santa Barbara!
Our laboratory studies the brain serotonin matrix and its interactions with other cellular elements. Serotonin molecules are ancient signal carriers that control the behavior of a shark, the cognition of a human, and many other vertebrate neuroprocesses. In particular, we are interested in the stochastic organization of serotonin-releasing axons and their functional relationships with microglia and blood platelets. Some of these problems have immediate clinical relevance: nearly all mental disorders have been associated with dysfunction in serotonin signaling, and the platelet hyperserotonemia of autism remains an enigma after half a century of research. We use a wide range of approaches that include molecular neurobiology, comparative neuroanatomy, and complex-systems methods.
- A two-year postdoctoral researcher position is available in a new interdisciplinary project. The project investigates the stochastic process that underlies the self-organization of serotonergic fibers in the brain. Candidates should have experience in one or more of the following areas: confocal or light-sheet microscopy, tissue clearing techniques, neuronal cell cultures, or computer analysis of 3D-images (with programming experience). All application materials must be submitted by January 16, 2019. For more information about the project and application process, please see here.
- The laboratory has been awarded a CRCNS grant by the National Science Foundation (NSF). (August 2018)
- The laboratory has been awarded an R21 grant by the National Institute of Mental Health (NIMH). (June 2018)
- Riley Demos has received the Morgan Award for Academic Excellence in Psychological and Brain Sciences. (May 2018)
- Norma Brown has accepted a position in Dr. Mark Harnett's laboratory at MIT. (May 2018)
- A stochastic approach to serotonergic fibers in mental disorders. Biochimie (in press).
- Some galeomorph sharks express a mammalian microglia-specific protein in radial ependymoglia of the telencephalon. Brain Behav. Evol. 91: 17-30.
- A receptor-based analysis of local ecosystems in the human brain. BMC Neurosci. 18: 33.