Impulsive personality predicts dopamine-dependent changes in frontostriatal activity during component processes of working memory

TitleImpulsive personality predicts dopamine-dependent changes in frontostriatal activity during component processes of working memory
Publication TypeJournal Article
Year of Publication2007
AuthorsCools R, Sheridan M, Jacobs E, D'Esposito M
JournalJ Neurosci
Volume27
Issue20
Pagination5506-14
Date Published2007 May 16
ISSN1529-2401
KeywordsAdolescent, Adult, Brain Mapping, Corpus Striatum, Dopamine, Frontal Lobe, Humans, Impulsive Behavior, Memory, Photic Stimulation, Predictive Value of Tests, Psychomotor Performance, Reaction Time
Abstract

Dopaminergic drugs affect a variety of cognitive processes, but the direction and extent of effects vary across individuals and tasks. Paradoxical effects are observed, by which the same drug causes cognitive enhancing as well as adverse effects. Here, we demonstrate that individual differences in impulsive personality account for the contrasting effects of dopaminergic drugs on working memory and associated frontostriatal activity. We observed that the dopamine D2 receptor agonist bromocriptine improved the flexible updating (switching) of relevant information in working memory in high-impulsive subjects, but not in low-impulsive subjects. These behavioral effects in high-impulsive subjects accompanied dissociable effects on frontostriatal activity. Bromocriptine modulated the striatum during switching but not during distraction from relevant information in working memory. Conversely, the lateral frontal cortex was modulated by bromocriptine during distraction but not during switching. The present results provide a key link between dopamine D2 receptor function, impulsivity, and frontostriatal activity during component processes of working memory.

DOI10.1523/JNEUROSCI.0601-07.2007
Alternate JournalJ. Neurosci.
PubMed ID17507572
Grant ListDA02060 / DA / NIDA NIH HHS / United States
MH63901 / MH / NIMH NIH HHS / United States
NS40813 / NS / NINDS NIH HHS / United States